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Updated: Dec 23, 2025

A "Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors
Published on: December 2, 2022
G protein-coupled pH-sensing receptor OGR1 and metabolic acidosis-induced hypercalciuria
1Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Nephrology, Odense University Hospital, Odense, Denmark.
Abstract:
Nearly a century ago it was discovered that metabolic acidosis promotes hypercalciuria. Studies have described intrarenal and extrarenal mechanisms underlying calcium wasting in acidosis, in part by altering bone metabolism but also by directly inhibiting renal calcium transport. In this issue of Kidney International, Imenez Silva et al. report that ablation of the pH-sensing receptor ovarian cancer G protein-coupled receptor 1 in a murine model led to Na+/H+-exchanger isoform 3 redistribution in the kidney and dampens the hypercalciuric response to metabolic acidosis.
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