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Updated: Dec 23, 2025
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Aberrant expression of miR-21 in patients with inflammatory bowel disease: A protocol for systematic review and meta
Huimin Yan1, Xinyu Zhang2, Yi Xu3
1Clinical Research Center, Shijiazhuang Fifth Hospital.
Background:
microRNAs have drawn more attention due to their function on the inflammatory process. The association between microRNA-21 (miR-21) expression and risk of inflammatory bowel diseases (IBD) remain inconclusive. This study was aimed to acquire a more exact estimation of this relationship.
Methods:
Relevant studies were identified through searching PubMed, Embase, Wanfang, and China National Knowledge Infrastructure database. Pooled standardized mean difference and 95% confidence intervals were calculated using a random-effect model. Publication bias test, sensitivity analysis and subgroup analysis were carried out.
Results:
A total of 20 relevant articles comprising 540 patients with ulcerative colitis (UC), 459 patients with Crohn disease (CD) and 511 non-IBD controls were included in this analysis. The expression of miR-21 was significantly increased in colon tissue of both UC and CD patients compared with non-IBD controls. However, there were no significant differences between patients with UC and CD. Moreover, increased miR-21 expression was associated with disease activity status in UC patients, but not in CD patients.
Conclusions:
This meta-analysis demonstrates that the higher miR-21 expression in colon tissue is positively associated with the development of UC and CD, and miR-21 might serve as a disease marker of IBD.
Insights
Higher microRNA-21 (miR-21) expression in colon tissue is linked to inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn disease (CD). This finding suggests miR-21 may be a potential biomarker for IBD development.
Area of Science:
- Molecular biology
- Gastroenterology
- Biomarker research
Background:
- MicroRNAs play a role in inflammatory processes.
- The link between microRNA-21 (miR-21) and inflammatory bowel diseases (IBD) requires further clarification.
Purpose of the Study:
- To precisely estimate the association between miR-21 expression and IBD risk.
- To evaluate miR-21 as a potential biomarker for IBD.
Main Methods:
- Systematic literature search of PubMed, Embase, Wanfang, and CNKI databases.
- Meta-analysis using a random-effect model to calculate pooled standardized mean differences and 95% confidence intervals.
- Publication bias, sensitivity, and subgroup analyses were performed.
Main Results:
- Included 20 studies with 540 ulcerative colitis (UC), 459 Crohn disease (CD) patients, and 511 controls.
- Significantly elevated miR-21 expression in colon tissue of both UC and CD patients compared to controls.
- miR-21 expression correlated with disease activity in UC but not in CD patients.
Conclusions:
- Increased miR-21 expression in colon tissue is associated with UC and CD development.
- miR-21 shows potential as a diagnostic marker for inflammatory bowel diseases.
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