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A prospective observational study to investigate the correlation analysis between neonatal hyperbilirubinemia and
Xiaohui Wu1,2, Xingqiang Gao2, Gang Li1
1Department of Otolaryngology Head and Neck Surgery, Hearing Center/Hearing and Speech Science Laboratory, West China Hospital of Sichuan University.
Insights
This study investigates hyperbilirubinemia in newborns and its link to hearing loss. By analyzing genes and audiometry data, researchers aim to identify genetic factors contributing to deafness in infants with elevated bilirubin levels.
Area of Science:
- Neonatal Medicine
- Genetics
- Audiology
Background:
- Hyperbilirubinemia is common in newborns.
- The link between hyperbilirubinemia and hearing impairment is established, but mechanisms remain unclear.
Purpose of the Study:
- To investigate the relationship between hyperbilirubinemia and hearing impairment in infants.
- To identify specific genes associated with high-frequency hearing loss in children with hyperbilirubinemia.
Main Methods:
- Sequencing of 127 deaf-related genes using high-throughput technology.
- Clinical data collection from 1000 infants with hyperbilirubinemia.
- Performing physical audiometry to record hearing data.
Main Results:
- Gene sequencing data will be combined with clinical hyperbilirubinemia information.
- Identification of genetic loci linked to high-frequency pathogenic deafness.
Conclusions:
- This research aims to provide early guidance for deafness gene screening in infants with hyperbilirubinemia.
- Understanding the genetic basis can aid in preventing hearing loss.
Introduction:
There are many studies on the relationship between serum levels of hyperbilirubinemia and hearing impairment. However, the mechanism of hyperbilirubinemia on auditory impairment is not clear.
Methods And Analysis:
A total of 1000 children with hyperbilirubinemia who are mainly indirectly elevated bilirubin in the full-term neonatal ward of Xiamen Children's Hospital from March 2020 to September 2020 will be enrolled. Using second-generation high-throughput sequencing technology, 127 deaf-related genes were sequenced from the collected samples. At the same time, physical audiometry was performed on the selected persons and audiometry data were recorded.
Discussion:
In this study, we will combine gene sequencing with clinical indications of hyperbilirubinemia to find the loci suitable for high-frequency pathogenic deafness related to hyperbilirubinemia, so as to provide early guidance for deafness gene screening in children with hyperbilirubinemia.
Trial Registration:
Chinese Clinical trial registry: ChiCTR2000030075.
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