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Relationship between quality of life and behavioural disorders in children with persistent asthma: a Multiple

Laura Montalbano1, Giuliana Ferrante2, Silvia Montella3

  • 1National Research Council of Italy, Institute for Research and Biomedical Innovation, IRIB, Via Ugo La Malfa 153, 90146, Palermo, Italy.

Scientific Reports
|April 26, 2020
PubMed

Insights

Severe asthma significantly impacts children's quality of life (QoL) and behavioral issues more than moderate asthma. Impaired QoL is a strong predictor of borderline status in children with asthma.

Area of Science:

  • Pediatric Pulmonology
  • Child Psychology
  • Health Outcomes Research

Background:

  • The interplay between asthma severity, control, quality of life (QoL), and behavioral problems in children is not fully understood.
  • Asthma management often focuses on physical symptoms, potentially overlooking psychological and social well-being.

Purpose of the Study:

  • To investigate the relationship between QoL, behavioral problems, asthma severity, and control in children.
  • To determine if QoL variations can predict "abnormal/borderline" status in pediatric asthma patients.

Main Methods:

  • A multicenter case-control study involving 47 children with Severe Asthma (SA) and 94 with Moderate Asthma (MA).
  • Utilized the MIMIC (Multiple Indicators Multiple Causes) approach to analyze the effects of SA and non-controlled asthma (NC) on QoL and behavioral disorders.
  • Employed logistic regression to predict the probability of "abnormal/borderline" status based on QoL variations.

Main Results:

  • The MIMIC model indicated that Severe Asthma (SA) and non-controlled asthma (NC) had a greater impact on QoL (β = -0.37 and β = -0.30) compared to behavioral problems (β = 0.27).
  • Children with Moderate Asthma (MA) had an 81% probability of borderline status with a QoL score of 1, while children with Severe Asthma (SA) had an 89% probability.
  • Severe asthma is strongly associated with significantly impaired QoL and increased behavioral problems in children.

Conclusions:

  • Severe asthma in children is linked to substantial impairments in quality of life and behavioral issues.
  • The MIMIC model provides a robust framework for comprehensively assessing the impact of asthma severity and control on QoL and behavioral problems.
  • Healthcare providers should consider QoL and behavioral assessments as crucial components in managing pediatric asthma, particularly severe cases.

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