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On the interactions of charged side chains with the alpha-helix backbone
1Department of Biophysics, Institute, University of Warsaw, Poland.
Biophysical Chemistry
|August 1, 1988
Abstract:
The effects of the position of charged amino acid side chains on the stability of the alpha-helix are investigated. Calculations for the model polyAla 13 residue alpha-helix, with modifications based on experimental work, are performed at three levels of approximation. The observed stabilization of the alpha-helix could be explained by interactions between its macrodipole and charged amino acid side chains. Limitations of the model are discussed.