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Related Concept Videos

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The graph of a function where each output is the square of the input creates a smooth curve that bends upward, becoming steeper as one moves further from the center. At any chosen position along this curve, the curve reaches a certain height depending on the input value. This position can be a reference for analyzing how the curve behaves in its immediate vicinity.To understand the change in the curve near a particular position, imagine selecting another point slightly ahead along the curve.
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True Stress and True Strain01:28

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Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
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Related Experiment Video

Updated: Dec 23, 2025

Method to Measure Tone of Axial and Proximal Muscle
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Method to Measure Tone of Axial and Proximal Muscle

Published on: December 14, 2011

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A tensed Tendyne.

Daniel Grinberg1,2, Matteo Pozzi1, Chloé Bernard1,3

  • 1Cardiovascular Surgery, Hopital Cardiologique Louis Pradel, Lyon, France.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|April 26, 2020
PubMed
Summary
This summary is machine-generated.

Prosthesis dislodgement after transcatheter mitral valve replacement (TMVR) is a rare complication. This case highlights the need for careful assessment of myocardial quality and appropriate prosthesis sizing to prevent TMVR complications.

Keywords:
MitralTendyneTranscatheter valveimplantationvalve

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Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Transcatheter mitral valve replacement (TMVR) offers a minimally invasive option for patients with severe mitral valve disease.
  • The Tendyne® system is one such TMVR device, utilizing an apical tether for fixation.
  • Ensuring secure prosthesis anchoring remains a critical challenge in TMVR development.

Observation:

  • An 85-year-old woman with chronic ischemic heart failure underwent successful transcatheter mitral valve replacement.
  • Two weeks post-procedure, she developed a paravalvular leak and left ventricular outflow tract obstruction due to prosthesis dislodgement.
  • Tether re-tensioning temporarily resolved the obstruction but caused apical deformation.

Findings:

  • The case illustrates prosthesis dislodgement as an infrequent but serious complication of the Tendyne® TMVR procedure.
  • Severe endocarditis ultimately led to the patient's expiration.
  • The event underscores the technical challenges related to prosthesis anchoring in TMVR.

Implications:

  • Accurate assessment of the apical myocardium's quality at the implantation site is crucial for TMVR success.
  • Appropriate prosthesis oversizing should be considered, particularly with low-profile valve designs.
  • Further research into robust anchoring mechanisms is essential for advancing TMVR safety and efficacy.