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Updated: Dec 23, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Experiential knowledge in clinical medicine: use and justification
Mark R Tonelli1, Devora Shapiro2
1University of Washington, 1959 NE Pacific St., Box 356522, Seattle, WA, 98195-6522, USA. tonelli@uw.edu.
Evidence-based medicine (EBM) undervalues clinicians' primary experience, dismissing it as anecdotal. This study argues that experiential knowledge is crucial for effective diagnosis and treatment, complementing research findings.
Area of Science:
- Medical Practice
- Epistemology
- Clinical Decision-Making
Background:
- Evidence-based medicine (EBM) acknowledges clinical expertise but undervalues primary patient experience.
- Clinicians' firsthand experience is often dismissed as anecdotal or biased, rather than a source of valid knowledge.
- The EBM framework presents an epistemic inconsistency by valuing expertise while distrusting its experiential foundation.
Purpose of the Study:
- To advocate for the value and utility of knowledge derived from primary clinical experience.
- To challenge the dismissal of experiential knowledge within the evidence-based medicine paradigm.
- To highlight the distinct yet crucial role of experiential knowledge alongside propositional knowledge in patient care.
Main Methods:
- Philosophical argument and conceptual analysis.
- Critique of existing hierarchies of evidence in clinical decision-making.
- Examination of the relationship between propositional and experiential knowledge in medicine.
Main Results:
- Primary clinical experience provides essential knowledge for diagnosing, treating, and assessing patient responses.
- Hierarchies of evidence often misrepresent the interplay between propositional and experiential knowledge.
- Experiential knowledge is a distinct and vital form of medical knowledge.
Conclusions:
- Clinical expertise, rooted in primary experience, is indispensable for optimal medical practice.
- Experiential knowledge is as crucial as propositional knowledge from research for determining patient-specific diagnoses and treatments.
- Reintegrating the value of primary experience is necessary for a more coherent and effective approach to evidence-based medicine.
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