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Current status of potential therapeutic candidates for the COVID-19 crisis

Jiancheng Zhang1, Bing Xie2, Kenji Hashimoto3

  • 1Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Brain, Behavior, and Immunity
|April 26, 2020
PubMed

Insights

This review explores potential treatments for coronavirus disease 2019 (COVID-19), including supportive care, immunomodulatory agents, and antiviral therapies. Research is ongoing to find effective COVID-19 treatments.

Area of Science:

  • Infectious Diseases
  • Virology
  • Internal Medicine

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents a significant global health and economic challenge.
  • As of April 15, 2020, over 1.87 million infections were reported worldwide.
  • No specific antiviral treatment for COVID-19 was established at the time of this review.

Purpose of the Study:

  • To summarize current and potential therapeutic strategies for COVID-19.
  • To review the mechanisms of action, safety, and effectiveness of various treatments.
  • To highlight ongoing research and clinical trials for novel COVID-19 therapies.

Main Methods:

  • Literature review of existing research on respiratory viral infections.
  • Analysis of clinical data and case studies for COVID-19 treatments.
  • Summary of ongoing clinical trials assessing drug efficacy and therapeutic targets.

Main Results:

  • Several therapeutic approaches, including supportive care, immunomodulatory agents, antiviral therapy, and convalescent plasma, have shown promise.
  • Some treatments have demonstrated substantial curative benefits in clinical settings.
  • Intensive research is actively exploring existing drugs and new therapeutic targets.

Conclusions:

  • A range of therapeutic interventions are being investigated for COVID-19 management.
  • Understanding treatment mechanisms, safety, and effectiveness is crucial for clinical application.
  • Continued research and clinical trials are essential for developing definitive treatments for COVID-19.

Keywords:
ACE2 blockerAntimalariaAntiviral: Chinese traditional medicineCOVID-19ImmunoenhancerMonoclonal antibodyVaccine

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