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ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Furong Liu1, Xin Long1, Bixiang Zhang1

  • 1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Wuhan, Hubei, China.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|April 26, 2020
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause pancreatic injury in COVID-19 patients. Researchers explored the virus receptor, angiotensin-converting enzyme 2 (ACE2), in the pancreas to understand this connection.

Area of Science:

  • Virology
  • Gastroenterology
  • Pathology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a global health crisis.
  • Pancreatic injury in COVID-19 patients is understudied but may affect prognosis.

Purpose of the Study:

  • To investigate the expression and distribution of angiotensin-converting enzyme 2 (ACE2) in the pancreas.
  • To determine the association between SARS-CoV-2 and pancreatic injury in COVID-19 patients.

Main Methods:

  • Exploration of ACE2 expression and distribution within pancreatic tissue.
  • Analysis of clinical data from COVID-19 patients.

Main Results:

  • ACE2, the SARS-CoV-2 receptor, is present in the pancreas.
  • Pancreatic injury was observed in a subset of COVID-19 patients.

Conclusions:

  • The pancreas is a potential site for SARS-CoV-2 infection due to ACE2 expression.
  • COVID-19 can lead to pancreatic injury, highlighting the need for clinical attention.

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