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Anti-cancer potential of sophoridine and its derivatives: Recent progress and future perspectives

Haroon Ur Rashid1, Shagufta Rasool2, Yousaf Ali2

  • 1Institute of Chemistry, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil; Department of Chemistry, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Bioorganic Chemistry
|April 26, 2020
PubMed

Insights

Sophoridine, a plant-derived alkaloid, shows significant antitumor activity. This review explores its anticancer potential, structure-activity relationships, and future development for novel cancer therapies.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Oncology

Background:

  • Cancer is a leading cause of global mortality, necessitating novel therapeutic strategies.
  • Phytoconstituents, including alkaloids like sophoridine, demonstrate promising anticancer effects.
  • Sophoridine, derived from Sophora species, is approved in China as an antitumor agent.

Purpose of the Study:

  • To review the antitumor activities of sophoridine and its derivatives.
  • To analyze structure-activity relationships (SAR) of sophoridine analogs.
  • To discuss the anticancer drug market and future prospects for sophoridine-based agents.

Main Methods:

  • Literature review of studies on sophoridine and its derivatives.
  • Analysis of reported half-maximal inhibitory concentration (IC50) values for efficacy.
  • Examination of SAR studies to understand key structural features for activity.

Main Results:

  • Sophoridine and its derivatives exhibit significant antitumor activities.
  • SAR studies provide insights into optimizing sophoridine analogs for enhanced efficacy.
  • The review details the efficacy of various sophoridine analogs.

Conclusions:

  • Sophoridine holds potential as a basis for developing new anticancer drugs.
  • Further research into sophoridine derivatives could lead to agents with improved efficacy and reduced toxicity.
  • Understanding SAR is crucial for designing next-generation sophoridine-based cancer therapies.
Keywords:
AlkaloidCancerPhytochemicalSophoridineTopoisomerase I

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