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Progression and Longitudinal Biometric Changes in Highly Myopic Eyes
Jonathan Tak Loong Lee1,1, Xinxing Guo1,1, Zhixi Li1
1,.
Investigative Ophthalmology & Visual Science
|April 26, 2020
Summary
Highly myopic eyes show progression throughout life, with younger individuals experiencing the fastest changes. Higher baseline myopia increases the risk of further myopic shift.
Area of Science:
- Ophthalmology
- Optometry
- Clinical Research
Background:
- High myopia (≤-6.00 diopters) is a significant ocular condition.
- Understanding progression patterns is crucial for managing visual health.
Purpose of the Study:
- To investigate the 2-year progression rate of high myopia.
- To analyze associated biometric changes in highly myopic eyes.
Main Methods:
- A longitudinal, observational cohort study.
- Included 657 participants (aged 7-70 years) with high myopia.
- Followed participants for 2 years with ocular biometry and refraction exams.
Main Results:
- A trend of increased myopia and axial elongation observed across all age groups.
- Younger participants (≤20 years) showed significantly higher progression rates.
- Adults aged 40-70 with high myopia continued to progress, especially those with extreme myopia (≤-10.00 D).
- Each diopter of baseline myopia increased the risk of a >1.00-D/y myopic shift by 11%.
Conclusions:
- Highly myopic eyes exhibit lifelong progression, with the highest rates in younger individuals.
- Axial elongation, primarily due to increased vitreous chamber depth, stabilizes post-20 years of age.
- Baseline myopia severity is a key risk factor for future myopic shifts.
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