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Related Experiment Video

Updated: Dec 23, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Brain morphologic abnormalities in migraine patients: an observational study.

Lilla Bonanno1, Viviana Lo Buono2, Simona De Salvo1

  • 1IRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Via Palermo, C. da Casazza, 98124, Messina, Italy.

The Journal of Headache and Pain
|April 27, 2020
PubMed
Summary
This summary is machine-generated.

Brain imaging reveals significant gray matter volume differences in migraine patients compared to healthy individuals. These findings in migraine with aura and without aura may help understand migraine pathogenesis.

Keywords:
AuraMagnetic resonance imagingMigraineNo AuraVoxel-based Morphometry

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Area of Science:

  • Neurology
  • Neuroimaging
  • Neuroscience

Background:

  • Migraine is a prevalent neurological disorder with complex underlying pathophysiology.
  • Understanding brain morphologic differences is crucial for elucidating migraine mechanisms.

Purpose of the Study:

  • To assess brain morphologic differences in migraine patients with and without aura compared to healthy subjects.
  • To investigate potential pathogenetic mechanisms underlying different migraine types.

Main Methods:

  • Magnetic Resonance Imaging (MRI) at 3.0 Tesla was used to analyze brain morphologic images.
  • Voxel-based morphometry (VBM) assessed gray matter volume (GMV) in 14 migraine with aura (MwA), 14 migraine without aura (MwoA), and healthy subjects (HS).
  • Statistical comparisons included unpaired t-tests and one-way ANOVA.

Main Results:

  • Significant differences in total cerebral GMV were observed between MwA and HS (p=0.02), and MwoA and HS (p=0.003).
  • No significant GMV differences were found between MwA and MwoA groups (p=0.17).
  • MwA and MwoA patients showed reduced GMV in the frontal lobe, temporal lobe, and cerebellum compared to HS. MwoA patients had increased GMV in the bilateral fusiform gyrus and cingulate gyrus compared to HS.

Conclusions:

  • The study identified distinct brain morphologic patterns in migraine with and without aura.
  • Findings suggest potential differences in the pathogenesis of these two migraine types.
  • These insights may contribute to a better understanding of migraine mechanisms.