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Augmented teicoplanin clearance through probable adsorption onto a polymethyl methacrylate (PMMA) hemofilter during

Kazutaka Oda1, Hirofumi Jono1, Katsuyuki Sagishima2

  • 1Department of Pharmacy, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto City, Kumamoto, 860-8556, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|April 27, 2020
PubMed

Insights

Teicoplanin clearance significantly increased during continuous venovenous hemodiafiltration (CVVHDF) with a polymethyl methacrylate (PMMA) hemofilter. Close monitoring of teicoplanin dosage is crucial when using PMMA membranes in CVVHDF patients.

Area of Science:

  • Pharmacokinetics
  • Nephrology
  • Infectious Diseases

Background:

  • Teicoplanin is a glycopeptide antibiotic effective against Gram-positive bacteria.
  • Continuous venovenous hemodiafiltration (CVVHDF) is a renal replacement therapy.
  • In-vitro studies suggest teicoplanin may adsorb to hemofilters.
Keywords:
AdsorptionContinuous venovenous hemodiafiltrationHemofilterPolymethyl methacrylateTeicoplanin

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