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Updated: Dec 23, 2025

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Locally invasive giant spinal paraganglioma
Bi Yi Chen1, Cezar Jose Mizrahi1, Yi Yang2
1Department of Neurosurgery, Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC 3000, Australia.
Abstract:
Cauda equina paragangliomas are neuroendocrine tumours rarely encountered in neurosurgical practice. Large cauda equina paragangliomas with an intradural and extradural component, dense adhesion to nerve roots and high vascularity are surgically challenging and mandate meticulous operative dissection. The presence of extensive bony erosion can lead to spinal instability requiring solid instrumentation and fixation. We recommend resection of large cauda equina paragangliomas in a staged fashion with the aim of gross total resection and spinal stabilisation.

