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Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

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Mammalian cell cycle cyclins

Diego Martínez-Alonso1, Marcos Malumbres1

  • 1Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO) Madrid, Spain.

Seminars in Cell & Developmental Biology
|April 27, 2020
PubMed

Insights

Cell cycle progression relies on cyclins and cyclin-dependent kinases (Cdks). This review focuses on key mammalian cyclins A, B, C, D, and E, their roles in various cell types, and links to human diseases.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cell division is a fundamental biological process.
  • Cyclins and cyclin-dependent kinases (Cdks) are key regulators of the cell cycle.
  • Dysregulation of cell cycle control is implicated in various diseases, including cancer.

Purpose of the Study:

  • To review the critical roles of specific mammalian cyclins (A, B, C, D, and E) in cell cycle progression.
  • To highlight the cell-type-specific functions of these cyclins in vivo.
  • To discuss the implications of cyclin dysregulation in human diseases.

Main Methods:

  • Literature review of existing research on cyclins and cell cycle regulation.
  • Analysis of studies focusing on cyclins A, B, C, D, and E.
  • Examination of in vivo data and human disease associations.

Main Results:

  • Cyclins A, B, C, D, and E are essential regulators of the mammalian cell cycle.
  • These cyclins exhibit distinct functions in different cell types and developmental stages.
  • Aberrant cyclin expression is linked to the pathogenesis of numerous human diseases.

Conclusions:

  • Understanding the precise roles of cyclins in cell cycle control is crucial for comprehending normal development and disease.
  • Targeting cyclin-dependent pathways holds potential for therapeutic interventions in human diseases.
Keywords:
CancerCell cycleCell proliferationCyclinCyclin-dependent kinase

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