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Related Experiment Video

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A tunable extruded 3D printing platform using thermo-sensitive pastes.

Yan Yang1, Xiaoyue Wang2, Xiao Lin2

  • 1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, USA.

International Journal of Pharmaceutics
|April 27, 2020
PubMed
Summary

This study presents a tunable 3D printing platform using thermo-sensitive gelatin pastes for personalized oral medicines. The technology enables flexible dosing and customized drug release profiles for immediate and sustained release formulations.

Keywords:
Computational fluid dynamics simulationExtruded 3D printingImmediate release matrixRheological studySustained release matrixThermo-sensitive gelatin paste

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Biomedical Engineering

Background:

  • Extruded 3D printing is a promising technology for personalized oral medicines.
  • Current methods may lack flexibility in drug release and dosing.

Purpose of the Study:

  • To develop a tunable extruded 3D printing platform using thermo-sensitive gelatin pastes.
  • To achieve varied drug release characteristics with flexible dosing and design.

Main Methods:

  • Systematic study of gelatin paste printability, extrusion, and deposition mechanisms.
  • Formulation and process parameter optimization for immediate-release (ibuprofen) and sustained-release (diclofenac sodium) drugs.
  • Rheological studies and computational fluid dynamics (CFD) simulations.

Main Results:

  • Successful printing of ibuprofen immediate-release and diclofenac sodium sustained-release formulations with target drug release patterns.
  • Identification of microcrystalline cellulose and hydroxypropyl methylcellulose as effective thickeners and proppants.
  • CFD simulations provided insights into extrusion flow dynamics.

Conclusions:

  • The thermo-sensitive gelatin paste platform demonstrates significant potential for personalized oral medicine fabrication.
  • Extruded 3D printing offers a versatile approach for tailoring drug delivery systems.
  • This technology facilitates flexible dosing and customized drug release profiles.