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SARS-CoV-2: Is it the newest spark in the TORCH?

Kathleen M Muldoon1, Karen B Fowler2, Megan H Pesch3

  • 1Department of Anatomy, College of Graduate Studies and Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, 85308, USA; National CMV Foundation, Tampa, FL, 33679, USA.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|April 27, 2020
PubMed

Insights

The COVID-19 pandemic impacts child health, necessitating inclusion of neonates and children in response plans. Research is crucial on prenatal SARS-CoV-2 acquisition and vaccine safety in pregnant individuals.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic presents unique challenges for child health.
  • Neonates and children's roles in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission require investigation.
  • Limited data exist on COVID-19 outcomes in pregnancy and congenital/perinatal infections.

Purpose of the Study:

  • To highlight the need for including pediatric considerations in pandemic preparedness.
  • To emphasize the importance of understanding prenatal and perinatal SARS-CoV-2 acquisition.
  • To advocate for evaluating vaccines in pregnant individuals, focusing on neonatal outcomes.

Main Methods:

  • Review of existing literature on coronaviruses (SARS, MERS) and congenital infections (CMV).
  • Analysis of the current state of knowledge regarding SARS-CoV-2 in pregnancy and neonates.
  • Discussion of public health priorities for prenatal and perinatal infection control.

Main Results:

  • Fetuses and newborns may be uniquely vulnerable to SARS-CoV-2.
  • Data on COVID-19 outcomes during pregnancy are scarce.
  • Understanding transmission routes in the prenatal/perinatal period is a high priority.

Conclusions:

  • Pandemic preparedness must address the specific needs of neonates and children.
  • Further research is essential on congenital/perinatal SARS-CoV-2 infection.
  • Clinical trials for vaccines in pregnant women should assess neonatal infection and disease endpoints.

Keywords:
COVID-19Congenital infectionSARS-CoV-2SARS-CoV-2 vaccinesTORCH infection

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