Update on treatment of COVID-19: ongoing studies between promising and disappointing results

Area of Science:

• Infectious Diseases
• Public Health
• Virology

Background:

• The COVID-19 pandemic is a major global health crisis, comparable to the 1918 influenza pandemic.
• A novel virus necessitates exploring existing antiviral agents used for SARS and MERS as initial treatment candidates.
• Various treatment guidelines and recommendations have emerged globally since the outbreak's inception.

Purpose of the Study:

• To review existing literature on COVID-19 treatments.
• To identify ongoing clinical trials investigating COVID-19 therapies.
• To highlight the urgent need for high-quality evidence on effective treatments.

Main Methods:

• A literature search was conducted using PubMed.
• The search focused on articles related to COVID-19 treatment.
• The search included ongoing clinical trials up to April 15, 2020.

Main Results:

• Several antiviral agents previously used for SARS and MERS were considered for COVID-19.
• Numerous clinical trials were initiated to evaluate potential COVID-19 therapies.
• The review aimed to consolidate information on treatments and ongoing research.

Conclusions:

• The rapid spread of COVID-19 prompted the consideration of repurposed antiviral drugs.
• A significant number of clinical trials underscore the urgent need for evidence-based treatment strategies.
• Continued research and evidence synthesis are critical for managing the pandemic.