Related Experiment Video
Updated: Dec 23, 2025

Studying the Protein Quality Control System of D. discoideum Using Temperature-controlled Live Cell Imaging
Published on: December 2, 2016
Correction to: Heat and chilling stress induce nucleolus morphological changes
Kohma Hayashi1, Sachihiro Matsunaga2
1Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278‑8510, Japan.
This study reveals how heat and chilling stress impact the nucleolus, a key cellular component. Understanding these morphological changes is crucial for cell biology research.
Area of Science:
- Cell Biology
- Environmental Stress Response
Background:
- The nucleolus is a vital cellular organelle involved in ribosome biogenesis and stress response.
- Environmental factors like temperature extremes can significantly affect cellular structures and functions.
Purpose of the Study:
- To investigate the morphological alterations of the nucleolus under conditions of heat and chilling stress.
- To elucidate the cellular mechanisms underlying stress-induced nucleolar changes.
Main Methods:
- Exposure of cells to controlled heat and chilling stress conditions.
- Microscopic analysis to observe nucleolus morphology.
- Quantitative assessment of structural changes.
Main Results:
- Both heat and chilling stress induce significant morphological changes in the nucleolus.
- Specific alterations include changes in size, shape, and internal structure of the nucleolus.
- These changes indicate a disruption of normal nucleolar function under stress.
Conclusions:
- Nucleolus morphology is sensitive to thermal stress.
- Understanding these stress-induced changes is important for comprehending cellular resilience and adaptation.
- The findings contribute to the broader understanding of cellular responses to environmental challenges.
More Related Videos
16:27Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
Published on: September 14, 2011
09:15Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
Published on: May 9, 2020
Related Concept Videos
The Nucleolus
The Nucleolus
Bacterial Protein Maturation
Other Stress Responses in Bacteria
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...
Nucleosome Remodeling
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...