Related Experiment Video
Updated: Dec 23, 2025
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury
Md Jamal Uddin1, Debra Dorotea1, Eun Seon Pak1
1Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Abstract:
Acute kidney injury (AKI) is a common disease with a complex pathophysiology which significantly contributes to the development of chronic kidney disease and end stage kidney failure. Preventing AKI can consequently reduce mortality, morbidity, and healthcare burden. However, there are no effective drugs in use for either prevention or treatment of AKI. Developing therapeutic agents with pleiotropic effects covering multiple pathophysiological pathways are likely to be more effective in attenuating AKI. Fyn, a nonreceptor tyrosine kinase, has been acknowledged to integrate multiple injurious stimuli in the kidney. Limited studies have shown increased Fyn transcription level and activation under experimental AKI. Activated Fyn kinase propagates various downstream signaling pathways associated to the progression of AKI, such as oxidative stress, inflammation, endoplasmic reticulum stress, as well as autophagy dysfunction. The versatility of Fyn kinase in mediating various pathophysiological pathways suggests that its inhibition can be a potential strategy in attenuating AKI.
Insights
Preventing acute kidney injury (AKI) is crucial for reducing long-term kidney damage. Targeting Fyn kinase, a key player in AKI pathways, shows promise for new therapeutic strategies.
Area of Science:
- Nephrology
- Molecular Biology
- Biochemistry
Background:
- Acute kidney injury (AKI) is a prevalent condition with severe consequences, including progression to chronic kidney disease and end-stage renal failure.
- Current therapeutic options for AKI are limited, highlighting the need for novel preventative and treatment strategies.
- Developing drugs with multifaceted effects is essential for addressing AKI's complex pathophysiology.
Purpose of the Study:
- To investigate the role of Fyn, a nonreceptor tyrosine kinase, in the development and progression of AKI.
- To explore the potential of Fyn inhibition as a therapeutic strategy for attenuating AKI.
Main Methods:
- Review of existing literature on Fyn kinase and its involvement in kidney injury.
- Analysis of studies demonstrating increased Fyn transcription and activation in experimental AKI models.
- Examination of downstream signaling pathways modulated by Fyn kinase in the context of AKI.
Main Results:
- Fyn kinase integrates multiple injurious stimuli in the kidney, contributing to AKI.
- Activated Fyn kinase promotes AKI progression through pathways including oxidative stress, inflammation, endoplasmic reticulum stress, and autophagy dysfunction.
- Limited studies indicate elevated Fyn levels and activity during experimental AKI.
Conclusions:
- Fyn kinase is a central mediator of diverse pathophysiological pathways implicated in AKI.
- Inhibiting Fyn kinase represents a promising therapeutic avenue for mitigating AKI.
- Targeting Fyn may offer a novel strategy to prevent AKI and its long-term sequelae.
Related Concept Videos
01:20Acute Kidney Injury V: Interprofessional Care
01:29Acute Kidney Injury II: Pathophysiology
01:22Acute Kidney Injury I: Introduction
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:22Acute Kidney Injury VI: Nursing Management
01:29Acute Kidney Injury III: Clinical Manifestations