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Neural Tube Closure in Mouse Whole Embryo Culture
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Junctional Neural Tube Defect.

Sebastian Eibach1,2,3, Dachling Pang4,5

  • 1Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Journal of Korean Neurosurgical Society
|April 28, 2020
PubMed
Summary
This summary is machine-generated.

Junctional neurulation is a newly identified developmental process. Its associated defect, junctional neural tube defect (JNTD), involves spinal cord separation and functional disconnection, as seen in recent patient cases.

Keywords:
EmbryologyNeural tube defectsNeurulationSpinal dysraphism

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Area of Science:

  • Developmental biology
  • Embryology
  • Neuroscience

Background:

  • Junctional neurulation is a recent addition to primary and secondary neurulation.
  • The molecular mechanisms of junctional neurulation are under active investigation.
  • Junctional neural tube defects (JNTDs) represent a pathological counterpart to this process.

Purpose of the Study:

  • To review the clinical, neuroimaging, and electrophysiological features of JNTD.
  • To discuss the embryogenetic mechanism hypothesis for JNTD.
  • To consolidate understanding of this rare neural tube defect.

Main Methods:

  • Literature review of JNTD cases.
  • Analysis of clinical presentations.
  • Review of neuroimaging and electrophysiological findings.

Main Results:

  • JNTD is characterized by a separated and functionally disconnected primary and secondary neural tube.
  • Several cases confirm the existence and distinct features of JNTD.
  • A hypothesis for the embryogenetic mechanism of JNTD is proposed.

Conclusions:

  • JNTD is a valid and distinct entity within neural tube defects.
  • Understanding JNTD sheds light on the complex processes of neurulation.
  • Further research is needed to fully elucidate the molecular basis and clinical management of JNTD.