Magnesium intoxication in women with preeclampsia with severe features treated with magnesium sulfate

To evaluate the maternal-neonatal outcome in magnesium (Mg)-intoxicated women with preeclampsia with severe features (PESF) treated with magnesium sulfate (MgSO₄).

A total of 19 Mg intoxicated PESF women (cases) were compared with 166 PESF women without signs of intoxication (controls).

Mg serum levels of cases was higher compared to control group (12.36 ± 3.54 mg/dl versus 2.69 ± 0.83 mg/dl). 3 women died and 3 had major maternal morbidity in cases group compared with zero in the control group (P = 0.009). Mg intoxication was also significantly associated with perinatal deaths and low Apgar scores at 1 and 5 minutes.

Mg intoxication is associated with a increased risk of maternal and perinatal mortality and morbidity.