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Studies on peroxidation of arachidonic acid in different liposomes below and above phase transition temperature
G Cervato1, P Viani, M Masserini
1Department of Medical Chemistry and Biochemistry, Faculty of Medicine, University of Milano, Italy.
Chemistry and Physics of Lipids
|November 1, 1988
Abstract:
The mechanism of Fe-induced peroxidation of arachidonic acid (AA) in small unilamellar vesicles (SUV) of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) was studied below and above gel to liquid-crystalline phase transition temperature (Tm). In both liposomes the AA peroxidation resulted higher in the temperature range below Tm, but the extent of malonyldialdehyde (MDA) formation was dramatically lower in DPPE vesicles when compared with corresponding DPPC liposomes. A possible explanation for this is discussed.