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Updated: Dec 23, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

8.6K

Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis

Katherine B Hisert1, Timothy P Birkland1, Kelly Q Schoenfelt2

  • 1Dept of Medicine, University of Washington, Seattle, WA, USA.

ERJ Open Research
|April 28, 2020
PubMed

Insights

This study shows that starting ivacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, benefits individuals with cystic fibrosis. Early treatment with ivacaftor improves health outcomes for eligible patients.

Area of Science:

  • Medical Research
  • Pharmacology

Background:

  • Cystic fibrosis (CF) is a genetic disorder affecting multiple organs.
  • The cystic fibrosis transmembrane conductance regulator (CFTR) protein is crucial for ion transport.
  • Defective CFTR function leads to CF symptoms.

Purpose of the Study:

  • To evaluate the impact of initiating ivacaftor treatment in individuals with cystic fibrosis.
  • To assess the clinical benefits and outcomes associated with ivacaftor therapy.

Main Methods:

  • Observational study design.
  • Analysis of patient data following ivacaftor initiation.
  • Assessment of relevant clinical endpoints.

Main Results:

  • Initiation of ivacaftor demonstrated positive effects in people with cystic fibrosis.
  • Specific susceptible populations showed notable improvements.
  • Further details on efficacy and safety are presented.

Conclusions:

  • Ivacaftor is an effective modulator for treating cystic fibrosis in susceptible individuals.
  • Early initiation of CFTR modulator therapy can be beneficial.
  • This highlights the importance of personalized medicine in CF treatment.

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