Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder.

Area of Science:

• Neonatal Medicine
• Biochemistry
• Pulmonology

Background:

• Transient tachypnea of the newborn (TTN) is a common respiratory issue in neonates.
• Early diagnosis of TTN is crucial for timely intervention and improved outcomes.

Purpose of the Study:

• To investigate the potential of HE4 (human epididymis protein 4) as a biomarker for early TTN diagnosis.
• To compare HE4 levels in mothers' blood, umbilical cord blood, and neonatal serum.

Main Methods:

• HE4 levels were measured in maternal blood, umbilical cord blood, and neonatal serum samples.
• Correlation analysis was performed between HE4, C-reactive protein (CRP), and procalcitonin (PCT).
• Receiver operating characteristic (ROC) curve analysis was used to determine HE4 cut-off values.

Main Results:

• No significant differences in HE4 levels were found between maternal and umbilical cord blood samples.
• Elevated HE4 levels were observed in neonates diagnosed with TTN compared to healthy neonates.
• A positive correlation was noted between HE4 and CRP/PCT levels in neonates.
• A serum HE4 cut-off of 318.5 pmol/L demonstrated 73.9% sensitivity and 66.7% specificity for TTN diagnosis.

Conclusions:

• Serum HE4 shows promise as a candidate biomarker for the early detection of pulmonary dysfunction in newborns.
• HE4 levels may aid in differentiating TTN from other neonatal respiratory conditions.