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Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B

Yang Zhou1, Guifang Yang1, Huaping He1

  • 1Department of Emergency Medicine, The Second Xiangya Hospital of Central South University, 139 Renmin road, Changsha, Hunan Province 410011, China.

Biomed Research International
|April 28, 2020
PubMed

Insights

The triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio is linked to in-hospital mortality in acute type B aortic dissection. A TG/HDL-c ratio below 2.05 was associated with increased mortality in Chinese patients.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Health
  • Vascular Surgery

Background:

  • The triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio is implicated in various vascular and metabolic diseases.
  • Its specific role in acute type B aortic dissection (aTBAD) remains under-investigated.
  • Understanding this relationship is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the association between the TG/HDL-c ratio and in-hospital mortality in patients with acute type B aortic dissection.
  • To determine if this ratio serves as an independent predictor of mortality in this patient cohort.

Main Methods:

  • A retrospective analysis of 523 patients diagnosed with aTBAD between January 2015 and December 2018.
  • TG/HDL-c ratio was calculated by dividing triglyceride levels by high-density lipoprotein cholesterol levels.
  • Statistical models were employed to assess the relationship between the TG/HDL-c ratio and in-hospital mortality, adjusting for potential confounders.

Main Results:

  • A significant positive and nonlinear relationship was observed between the TG/HDL-c ratio and in-hospital mortality.
  • An inflection point was identified at a TG/HDL-c ratio of 2.05.
  • Mortality risk was significantly elevated when the TG/HDL-c ratio was below 2.05 (OR = 3.17, 95% CI 1.54-6.57, P = 0.001).

Conclusions:

  • The TG/HDL-c ratio exhibits a nonlinear association with in-hospital mortality in Chinese patients with acute type B aortic dissection.
  • A TG/HDL-c ratio below 2.05 is identified as a significant risk factor for increased in-hospital mortality.
  • This lipid ratio may serve as a valuable biomarker for predicting outcomes in aTBAD.
Abstract

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