Adult-Onset Immunoglobulin A Vasculitis

Area of Science:

• Nephrology
• Rheumatology
• Pediatrics

Background:

• Immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schönlein purpura, is a systemic vasculitis.
• IgAV is predominantly diagnosed in pediatric populations, with adult cases being infrequent.
• Common clinical manifestations include palpable purpura, arthralgia, abdominal pain, and renal involvement.

Observation:

• A 56-year-old male presented with a month of progressive abdominal pain and a subsequent bilateral lower extremity rash.
• Initial laboratory tests revealed acute kidney injury.
• Imaging and endoscopic evaluation identified terminal ileitis.

Findings:

• Kidney biopsy confirmed the diagnosis of Immunoglobulin A vasculitis.
• The patient's presentation included characteristic IgAV symptoms: rash, abdominal pain, and renal involvement.

Implications:

• This case underscores the importance of considering IgAV in adult patients presenting with a combination of vasculitic rash, gastrointestinal symptoms, and acute kidney injury.
• Early diagnosis and appropriate management of adult IgAV are crucial to prevent long-term renal complications.