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Related Experiment Video

Updated: Dec 23, 2025

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
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A complex morphofunctional approach for zinc toxicity evaluation in rats.

Gennadii Piavchenko1,2,3, Alexander Alekseev3, Olga Stelmashchuk3

  • 1I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Federation.

Heliyon
|April 28, 2020
PubMed
Summary

Single-dose zinc succinate exposure in rats caused significant neurotoxicity and organ damage, including reduced motor activity and changes in brain NADH levels. This highlights long-term toxic effects even at low doses.

Keywords:
Behavioral activityEndogenous fluorescenceExperimental ratsHealth sciencesMorphofunctional approachNeurosciencePsychiatryTissue and organ toxicityToxicologyZinc succinate

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Area of Science:

  • Environmental Toxicology
  • Neurotoxicology
  • Biochemistry

Background:

  • Anthropogenic activities introduce zinc compounds into the environment, leading to accumulation and systemic toxicity.
  • Zinc accumulation primarily causes neurotoxicity, affecting respiratory, cardiovascular, and digestive systems.

Purpose of the Study:

  • To evaluate the long-term structural and functional effects of a single intragastric dose of zinc succinate (100 mg/kg) in male Wistar rats.
  • To assess neurobehavioral changes, coenzyme activity, and histological alterations in organs and tissues one month post-treatment.

Main Methods:

  • Morphofunctional assessment including automated behavioral analysis (Laboras® complex).
  • Fluorescent spectral analysis of NADH (nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide) activity.
  • Histological examination of cerebral cortex, heart, lungs, and liver tissues.

Main Results:

  • Significant decrease in motor activity observed in treated rats.
  • Reduced NADH levels without significant changes in FAD levels indicated metabolic disruption.
  • Toxic and dystrophic changes were identified in the cerebral cortex, heart, lungs, and liver.

Conclusions:

  • A single low dose of zinc succinate induces significant long-term neurotoxic and systemic effects.
  • The multiparametric approach effectively assesses the toxicity of metal salts like zinc succinate.
  • This study reveals detrimental impacts on the cerebral cortex at doses below acute toxicity levels.