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Effect of Blueberry Consumption on Cardiometabolic Health Parameters in Men with Type 2 Diabetes: An 8-Week,
Kim S Stote1, Margaret M Wilson2, Deborah Hallenbeck3
1Department of Research, Stratton VA Medical Center, Albany, NY, USA.
Background:
Blueberries are dietary sources of polyphenols, specifically anthocyanins. Anthocyanins have been identified as having a strong association with type 2 diabetes risk reduction; however, to date few human clinical trials have evaluated the potential beneficial health effects of blueberries in populations with type 2 diabetes.
Objectives:
We investigated the effects of blueberry consumption for 8 wk on cardiometabolic parameters in men with type 2 diabetes.
Methods:
In a double-blind, parallel-arm, randomized controlled trial, 52 men who are US veterans [mean baseline characteristics: age, 67 y (range: 51-75 y); weight, 102 kg (range: 80-130 kg); BMI (in kg/m2), 34 (range: 26-45)] were randomly assigned to 1 of 2 intervention groups. The interventions were either 22 g freeze-dried blueberries or 22 g placebo. The study participants were asked to consume 11 g freeze-dried blueberries or placebo with each of their morning and evening meals along with their typical diet.
Results:
Mean ± SE hemoglobin A1c (7.1% ± 0.1% compared with 7.5% ± 0.2%; P = 0.03), fructosamine (275.5 ± 4.1 compared with 292.4 ± 7.9 µmol/L; P = 0.04), triglycerides (179.6 ± 10.1 compared with 199.6 ± 19.9 mg/dL; P = 0.03), aspartate transaminase (23.2 ± 1.4 compared with 30.5 ± 2.7 units/L; P = 0.02), and alanine transaminase (35.6 ± 1.5 compared with 48.3 ± 2.9 units/L; P = 0.0003) were significantly lower for those consuming blueberries for 8 wk than for those consuming the placebo. Fasting plasma glucose concentrations; serum insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and C-reactive protein concentrations; blood pressure; and body weight were not significantly different after 8 wk consumption of blueberries compared with the placebo.
Conclusions:
Consumption of 22 g freeze-dried blueberries for 8 wk may beneficially affect cardiometabolic health parameters in men with type 2 diabetes.This trial was registered at clinicaltrials.gov as NCT02972996.
Insights
Daily consumption of blueberries may improve cardiometabolic health in men with type 2 diabetes. This study found significant reductions in hemoglobin A1c, fructosamine, and triglycerides in participants who consumed blueberries.
Area of Science:
- Nutritional Science
- Cardiovascular Health
- Diabetes Management
Background:
- Blueberries are rich in anthocyanins, potent polyphenols linked to reduced type 2 diabetes risk.
- Limited human trials have explored blueberry's health impacts in individuals with type 2 diabetes.
Purpose of the Study:
- To investigate the effects of 8-week blueberry consumption on cardiometabolic parameters in men with type 2 diabetes.
Main Methods:
- A double-blind, randomized controlled trial involving 52 US veteran men with type 2 diabetes.
- Participants consumed 22g of freeze-dried blueberries or a placebo daily for 8 weeks.
Main Results:
- Blueberry consumption significantly lowered hemoglobin A1c, fructosamine, triglycerides, aspartate transaminase, and alanine transaminase.
- No significant differences were observed in fasting plasma glucose, insulin, cholesterol levels, C-reactive protein, blood pressure, or body weight.
Conclusions:
- Eight weeks of daily blueberry intake may offer cardiometabolic benefits for men with type 2 diabetes.
- Further research is warranted to confirm these findings and explore underlying mechanisms.
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