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Is it time for computable evidence synthesis?

Adam G Dunn1,2,3, Florence T Bourgeois3,4

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Summary
This summary is machine-generated.

Structured trial registry data offers a more timely and complete alternative to published articles for evidence synthesis. Utilizing these sources can enhance systematic reviews and create a continuous evidence surveillance system.

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Area of Science:

  • Medical Informatics
  • Clinical Trials
  • Evidence-Based Medicine

Background:

  • Published articles are a delayed, incomplete, and potentially biased source for evidence synthesis.
  • Structured results data in trial registries are underutilized despite being more timely and accessible.

Purpose of the Study:

  • To highlight the advantages of using structured trial registry data for evidence synthesis.
  • To advocate for a shift towards utilizing emerging sources of structured trial data.

Main Methods:

  • Analysis of the characteristics and accessibility of data in trial registries versus published articles.
  • Exploration of the potential applications of structured trial data in systematic reviews.

Main Results:

  • Structured trial registry data offers potential for automatic evidence monitoring and timely systematic review updates.
  • Prospective assignment of trials to published reviews is facilitated by structured registry data.

Conclusions:

  • Shifting focus to structured trial data can foster a more proactive and efficient continuous evidence surveillance system.
  • Increased utilization of trial registry data is crucial for advancing evidence synthesis methodologies.