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The Role of CARD9 in Metabolic Diseases

Cheng Tian1, Ya-Li Tuo1, Yi Lu1

  • 1Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Current Medical Science
|April 28, 2020
PubMed

Insights

Caspase recruitment domain containing protein 9 (CARD9) is crucial for inflammatory responses. This review highlights CARD9

Area of Science:

  • Immunology and Molecular Biology
  • Metabolic Disease Research

Background:

  • Caspase recruitment domain containing protein 9 (CARD9) acts as an adaptor protein.
  • CARD9 mediates pattern recognition receptor (PRR) signaling, activating NF-κB and MAPK pathways.
  • These pathways initiate pro-inflammatory cytokines, contributing to chronic inflammation and metabolic diseases.

Purpose of the Study:

  • To review the CARD9 signaling pathway.
  • To elucidate the role of CARD9 in metabolic diseases like obesity, insulin resistance, and atherosclerosis.

Main Methods:

  • Literature review of CARD9 signaling.
  • Analysis of CARD9's association with metabolic disorders.

Main Results:

  • CARD9 is integral to inflammatory signaling cascades.
  • Significant association observed between CARD9 and various metabolic diseases.

Conclusions:

  • CARD9 plays a pivotal role in linking inflammation to metabolic dysfunction.
  • Understanding CARD9 pathways offers therapeutic targets for metabolic diseases.

Keywords:
caspase recruitment domain containing protein 9metabolic diseasespattern recognition receptors

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