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Updated: Dec 23, 2025

Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
Published on: July 29, 2017
Primary tumor resection in de novo stage IV breast cancer patients
Craig Joshua Follette1, Clare Humphrey1, Amanda Amin1
1University of Kansas Medical Center - General Surgery, Kansas City, KS, USA.
Abstract:
Breast and axillary surgery in Stage IV disease is outside current national guidelines but has been a topic of ongoing debate. A single institution retrospective study identified women with de novo stage IV BC from 2011-2016 to evaluate the rate and goals of primary site surgery. Only 10.2% (n = 27/265patients) had primary site surgery. The goal of surgery was most often treatment intent (n = 23, 85.1%) not palliation (n = 4, 14.8%). There was no 30-day mortality and low (n = 1, 3.7%) 30-day morbidity. Multi-disciplinary patient care pathways based on modern evidence may help identify patients potentially suitable for primary site surgery.
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