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Updated: Dec 23, 2025
Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
Published on: April 19, 2024
Patients' recovery after severe TBI is associated with their close relatives' interpersonal functioning: a 12-months
Lynn H C Gaertner1,2, Noga Tsur3, Chiara S Haller1,4
1Department of Psychology, Harvard University , Cambridge, Massachusetts, USA.
Objective:
The aim of this study was to investigate the association between relatives' interpersonal functioning and patients' recovery after severe traumatic brain injury (TBI) across one year in Switzerland. Design: This prospective, multi-center cohort study is comprised of 188 adult patients with severe TBI (Abbreviated Head Injury Score > 3) and their relatives. Patients and relatives were assessed 3, 6, and 12 months post-injury. Main outcome measures: Interpersonal functioning (Patient Competency Rating Scale for Neurorehabilitation, PCRS-NR), Physical and Mental Health related Quality of Life (HRQoL, SF-12), and overall functioning (Glasgow Outcome Comma Scale Extended, GOSE). Results: Multilevel analyses showed that relatives' interpersonal functioning was positively associated with a) patients' mental HRQoL (p =.002; slope = 2.95; β =.24) independently of age, b) a moderation time*patients' physical HRQoL among patients > 50 years of age (p <.045; slope = 2.63; β =.2) and c) patients' GOSE among younger individuals (p <.001; slope =.60; β =.23). Conclusion: These findings show that health and overall functioning are linked with interpersonal dimensions. Thus, the interplay between relatives and patients with TBI needs to be further investigated.
