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Does Vitamin D Deficiency Predispose to Post Stroke Fatigue?

K Njoku1,2, E Iveson2

  • 1University of Manchester, School of Medical Sciences, Faculty of Biology, Medicine and Health, 5th Floor Research, St Mary's Hospital, Oxford Road, Manchester M13 9WL, United Kingdom.

Irish Medical Journal
|April 28, 2020
PubMed
Summary

Vitamin D deficiency is common in stroke survivors experiencing fatigue. Supplementation significantly improved fatigue symptoms, suggesting a potential treatment avenue.

Keywords:
FatigueStrokeSurvivorsVitamin D Deficiency

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Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • Fatigue is a common and debilitating symptom following a stroke.
  • Vitamin D deficiency is prevalent globally and may impact neurological recovery and function.
  • The relationship between vitamin D levels and fatigue in stroke survivors requires further investigation.

Purpose of the Study:

  • To determine the prevalence and associated factors of vitamin D deficiency in stroke survivors with fatigue.
  • To evaluate the impact of vitamin D supplementation on fatigue symptoms in this population.

Main Methods:

  • A retrospective observational study analyzing records of 58 stroke survivors with fatigue.
  • Vitamin D levels were assessed at presentation.
  • Statistical analysis included Pearson Chi Square and Fishers Exact tests for group comparisons.

Main Results:

  • The overall prevalence of vitamin D insufficiency was 74.5%, rising to 77.4% in ambulant survivors.
  • The majority of the 58 included survivors were female, over 75 years old, and had a modified Rankin Score (MRS) of <4.
  • One hundred percent of survivors treated with vitamin D supplementation showed significant improvement in fatigue symptoms.

Conclusions:

  • Stroke survivors with fatigue exhibit a high prevalence of vitamin D deficiency, unexpectedly high in ambulant individuals.
  • Correction of vitamin D deficiency led to substantial improvement in fatigue symptoms.
  • Further longitudinal randomized studies are warranted to confirm these findings and explore treatment options to enhance stroke survivors' quality of life.