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Updated: Dec 23, 2025

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
Published on: June 29, 2021
Metastatic spinal cord compression
Surendra Patnaik1, Joseph Turner2, Praveen Inaparthy1
1Department of Trauma and Orthopaedic Surgery, East Surrey Hospital, Surrey and Sussex Healthcare NHS Trust, Redhill, UK.
Abstract:
Metastatic spinal cord compression is compression of the spinal cord or cauda equina as a result of metastatic deposits in the spinal column. It affects approximately 4000 cases per year in England and Wales. Prompt identification and treatment of metastatic spinal cord compression is necessary to prevent irreversible neurological injury, treat pain and maintain patients' mobility, function and independence. Survival of patients with common malignancies has improved significantly with the ongoing development of radiotherapy and chemotherapy, as well as improved surgical treatment of resectable primary tumours. This article outlines the clinical approach to presentation, pathophysiology, diagnosis and management.
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