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Updated: Dec 23, 2025

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Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption.

John E Desmond1, Laura C Rice1, Dominic T Cheng1,2

  • 1Johns Hopkins University School of Medicine, Baltimore, Maryland.

Alcoholism, Clinical and Experimental Research
|April 28, 2020
PubMed
Summary
This summary is machine-generated.

Heavy chronic alcohol consumption alters brain

Keywords:
Alcohol Use DisorderHRFHemodynamic Response FunctionLifetime DrinkingUndershootfMRI

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Alcohol Research

Background:

  • Functional MRI (fMRI) analyses depend on the hemodynamic response function (HRF) to interpret brain activity.
  • While acute alcohol effects on HRF are known, chronic heavy alcohol use impacts remain unexplored.
  • The utility of individual HRF estimation in alcohol use disorder (AUD) fMRI studies is unclear.

Purpose of the Study:

  • To investigate the effects of chronic heavy alcohol consumption on the HRF.
  • To assess the impact of individual HRF estimation on fMRI analyses in AUD.

Main Methods:

  • Participants with AUD and controls underwent structural, functional, and vascular scans.
  • fMRI task involved finger tapping; motor cortex responses were analyzed.
  • HRFs were modeled using a difference of two gamma distributions to compute peak and undershoot timing.

Main Results:

  • HRF undershoot timing significantly increased with cumulative lifetime alcohol consumption.
  • Motor cortex gray matter reduction and vascular factors did not fully explain HRF timing shifts.
  • Subject-specific HRFs improved fMRI activation results in controls and most AUD regions, except basal ganglia.

Conclusions:

  • Excessive alcohol consumption is linked to alterations in the HRF undershoot.
  • HRF changes may serve as a biomarker for alcohol's long-term brain effects.
  • Individualized HRFs enhance fMRI activation measures in AUD research.