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Bowman's layer in the cornea- structure and function and regeneration.

Steven E Wilson1

  • 1Cole Eye Institute, I-32, Cleveland Clinic, 9500, Euclid Ave, Cleveland, OH, United States.

Experimental Eye Research
|April 28, 2020
PubMed
Summary
This summary is machine-generated.

Bowman's layer, a cornea component, is absent in many species and not essential for vision after removal. Its development may involve cytokine interactions between corneal cells.

Keywords:
Bowman's layerChemotaxisCorneaHistopathologyWound healing

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Area of Science:

  • Ophthalmology
  • Comparative Anatomy
  • Cell Biology

Background:

  • Bowman's layer is located between the corneal epithelium and stroma in various species.
  • Its presence varies significantly across species, being absent in domestic animals like dogs and horses.
  • Acquired damage is common in conditions like bullous keratopathy and Fuchs' dystrophy.

Purpose of the Study:

  • To investigate the functional significance and developmental origins of Bowman's layer.
  • To explore the role of Bowman's layer in protein transport and its necessity in corneal procedures.
  • To understand the cellular and molecular mechanisms underlying Bowman's layer formation.

Main Methods:

  • Comparative anatomical analysis across diverse species.
  • Review of clinical outcomes from photorefractive keratectomy (PRK) procedures.
  • Examination of protein transport across Bowman's layer.
  • Hypothesizing developmental pathways based on cytokine interactions.

Main Results:

  • Bowman's layer is not universally present across mammalian and avian species.
  • Photorefractive keratectomy (PRK) involving Bowman's layer removal shows no adverse effects.
  • The collagen structure of Bowman's layer does not significantly impede moderate to large protein passage.
  • A "Bowman's like layer" can form post-surgery or in specific corneal conditions.

Conclusions:

  • Bowman's layer lacks a significant barrier function for proteins.
  • Its absence or removal, as in PRK, does not negatively impact corneal function.
  • Cytokine-mediated interactions between epithelial cells and keratocytes are hypothesized to drive its development.