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Subthalamic Deep Brain Stimulation Modulates Proprioceptive Integration in Parkinson's Disease During a Postural Task
M Vaugoyeau1, F Cignetti2, A Eusebio3
1CNRS, Aix Marseille Univ, LNC UMR 7291, Marseille, France; CNRS, Aix Marseille Univ, Fédération 3C FR 3512, Marseille, France.
Neuroscience
|April 28, 2020
Summary
Parkinson's disease patients exhibit impaired proprioceptive integration, affecting postural control. Deep brain stimulation of the subthalamic nucleus (STN-DBS) shows potential to improve this integration and enhance balance in PD patients.
Area of Science:
- Neuroscience
- Movement Disorders
- Rehabilitation Medicine
Background:
- Proprioceptive integration deficits are implicated in Parkinson's disease (PD) pathophysiology.
- Previous research on proprioceptively-evoked postural reactions in PD patients has yielded limited and conflicting results.
- The precise role of proprioception in PD-related postural impairment remains unclear.
Purpose of the Study:
- To investigate if proprioceptive deficits contribute to postural instability in Parkinson's disease.
- To determine the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on proprioceptive integration in PD patients.
Main Methods:
- A muscle-tendon vibration paradigm was employed to assess proprioceptive integration during postural tasks.
- Center of pressure displacement and kinematic data were analyzed in 13 PD patients and 12 age-matched controls.
- Comparison of postural control between PD patients and controls, with and without STN-DBS.
Main Results:
- Parkinson's disease patients demonstrated reduced postural stability and impaired vertical orientation compared to controls.
- Patients with STN-DBS showed significant improvements in postural orientation and balance.
- PD patients, even without overt instability, utilize proprioceptive information less effectively for postural control.
Conclusions:
- Proprioceptive deficits contribute to postural control impairments in Parkinson's disease.
- Subthalamic nucleus deep brain stimulation (STN-DBS) can enhance proprioceptive integration, positively impacting balance and orientation in PD.
- These findings highlight a potential therapeutic target for improving motor function in Parkinson's disease.
Keywords:
Deep brain stimulation of the subthalamic nucleusParkinson's diseasepostural controlproprioceptionMore Related Videos
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