Related Experiment Video
Updated: Dec 23, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
The effects of delta-9-tetrahydrocannabinol (THC) on inflammation: A review
Henry P Miller1, Steven C Bonawitz1, Olga Ostrovsky2
1Department of Surgery, Cooper University Hospital, Camden, NJ, USA.
Abstract:
THC is the main psychoactive compound found in marijuana. A number of studies over the past few decades, both in vitro and in vivo, have demonstrated that THC down-regulates the inflammatory process through various mechanisms. Similar findings have been demonstrated with CBD, the other major bioactive component of marijuana. Given the essential role that inflammation plays in early wound healing, it is possible that marijuana, or its individual constituents, may impact this process. Herein, we review the existing literature related to the effects of THC on inflammation and potentially wound healing, and discuss how this connection may be relevant from a surgical perspective.
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