Related Experiment Videos
A new application of in situ hybridization: detection of numerical and structural chromosome aberrations with a
1Radiobiological Institute TNO, Rijswik, The Netherlands.
Cytogenetics and Cell Genetics
|January 1, 1988
Abstract:
Fluorescent in situ hybridization provides a fast method for detection of specific nucleic acid sequences. We have used high-resolution, single-color fluorescent in situ hybridization with a combination centromeric-telomeric DNA probe, specific for chromosome 1, to investigate the feasibility of simultaneous assessment of numerical and structural chromosome aberrations. The K562 leukemia cell line served as a model.