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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

474
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
474
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

639
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
639
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

413
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
413

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Related Experiment Video

Updated: Dec 23, 2025

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

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Pulmonary enteric adenocarcinoma: an overview.

Raffaele Palmirotta1, Domenica Lovero1, Stella D'Oronzo1,2

  • 1Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', P.zza G. Cesare, 11 - 70124Bari, Italy.

Expert Reviews in Molecular Medicine
|April 29, 2020
PubMed
Summary

Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare lung cancer. Research highlights its immunohistochemical and molecular markers for diagnosis and treatment, differentiating it from colorectal cancer.

Keywords:
Clinicopathological findingsimmunohistochemistrymutation profilepulmonary adenocarcinoma with enteric differentiation (PAED)pulmonary enteric adenocarcinoma (PEAC)

Related Experiment Videos

Last Updated: Dec 23, 2025

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare, heterogeneous lung cancer variant.
  • It shares features with pulmonary and colorectal adenocarcinomas, complicating diagnosis.

Purpose of the Study:

  • To summarize current research on PAED, focusing on diagnostic and prognostic markers.
  • To explore therapeutic implications and differential diagnosis from colorectal cancer.

Main Methods:

  • Systematic review and analysis of published literature on PAED.
  • Data compilation from 295 patients across 58 articles.

Main Results:

  • PAED often shows enteric morphology and markers (CDX2, CK20, MUC2), mimicking colorectal cancer.
  • Identified key immunohistochemical and molecular markers and regional differences (Asia vs. Europe/North America).

Conclusions:

  • Specific immunohistochemical and molecular signatures are crucial for PAED diagnosis and management.
  • Further molecular studies may reveal prognostic factors and guide tailored therapies for this rare neoplasm.