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Hepatitis B-management of acute infection and active inflammation in pregnancy-a hepatologist's perspective

Grace Lai-Hung Wong1, Wan-Hsin Wen2, Calvin Q Pan3

  • 1The Chinese University of Hong Kong, Hong Kong SAR, China.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|April 29, 2020
PubMed

Women at childbearing age and pregnant ladies living in the areas of high or intermediate prevalence of hepatitis B virus (HBV) remain at risk of getting the infection and passing the infections to their offspring via mother-to-child transmission (MTCT) of HBV. HBV infection may affect the mothers by active hepatitis, very occasionally liver cirrhosis and rarely fulminant hepatitis and liver failure. The virus may be transmitted to the babies despite immunoprophylaxis in the setting of very high maternal viral load. Tenofovir disoproxil fumarate (TDF) has been shown to be efficacious to reduce MTCT of HBV, which contributes to the elimination of chronic HBV infection by 2030, the goal set by World Health Organization.

Keywords:
Acute hepatitisChronic hepatitisHepatitis B virusMother-to-child transmissionPregnancyTenofovir disoproxil fumarate

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