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Updated: Dec 23, 2025

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage

Published on: January 11, 2012

Repurposing a chemosensory macromolecular machine.

Davi R Ortega¹, Wen Yang², Poorna Subramanian¹

¹Division of Biology and Biological Engineering, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA, C1125, USA.

Nature Communications

|April 29, 2020

Summary

This summary is machine-generated.

The evolution of complex molecular machines, like the chemosensory system controlling bacterial flagellar motility in Escherichia coli, is revealed. Ancestral forms suggest a stress response pathway where one system was lost after another took over its functions.

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Last Updated: Dec 23, 2025

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Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Published on: February 23, 2011

Area of Science:

Microbiology
Evolutionary Biology
Biochemistry

Background:

The evolution of complex macromolecular machines is not well understood.
Chemosensory systems control essential cellular functions, including bacterial motility.

Purpose of the Study:

To investigate the evolutionary origins of the chemosensory machinery controlling flagellar motility in Escherichia coli.
To identify ancestral forms and trace the evolutionary trajectory of this system.

Main Methods:

Electron cryotomography to characterize ancestral structures.
Bioinformatic analysis to trace evolutionary events through γ-Proteobacteria.

Main Results:

Identified ancestral chemosensory machinery in Vibrio cholerae, Pseudomonas aeruginosa, Shewanella oneidensis, and Methylomicrobium alcaliphilum.
Evidence suggests these ancestral systems function in a stress response pathway.
Traced key evolutionary events in γ-Proteobacteria, revealing the takeover of one system (F7) by another (F6), leading to the loss of F6.

Conclusions:

The chemosensory system in E. coli evolved from at least two ancient systems.
One ancient system (F7) assumed the inputs and outputs of another (F6), which was subsequently lost.
This evolutionary process sheds light on the development of complex molecular machinery.