Related Experiment Video
Updated: Dec 23, 2025
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
3.1K
Thoughts on COVID-19 and autoimmune diseases
Anca D Askanase1, Leila Khalili1, Jill P Buyon2
1Department of Rheumatology, Columbia University Medical Center, New York, New York, USA.
Lupus Science & Medicine
|April 29, 2020
Summary
Patients with autoimmune diseases face unique challenges during the COVID-19 pandemic. Immunomodulatory therapies may help manage severe pneumonia by controlling the cytokine storm in these patients.
Area of Science:
- Immunology
- Infectious Diseases
- Rheumatology
Background:
- The rapid global spread of coronavirus disease 2019 (COVID-19) presents significant risks to all populations.
- Patients with autoimmune diseases may experience unique complications and challenges due to their underlying conditions and treatments.
Purpose of the Study:
- To discuss the potential challenges faced by patients with autoimmune diseases in the context of COVID-19.
- To review the role of immunomodulatory therapies in managing severe COVID-19 pneumonia.
Main Methods:
- Literature review and synthesis of current information regarding COVID-19 and autoimmune diseases.
- Discussion of immunomodulatory agents including chloroquine, tocilizumab, and baricitinib.
Main Results:
- COVID-19 poses a serious threat with a notable mortality rate.
- Autoimmune disease patients require careful consideration regarding infection risk and treatment management.
- Immunomodulatory therapies show potential in mitigating hyperinflammation (cytokine storm) in severe COVID-19 cases.
Conclusions:
- Understanding the intersection of autoimmune diseases and COVID-19 is critical for patient care.
- Strategic use of immunomodulatory drugs may be beneficial for severe COVID-19 pneumonia in autoimmune disease patients.
Related Concept Videos
01:29Autoimmune Disorders
1.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.3K
01:27Psychoneuroimmunology: Cardiovascular Disease
272
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
272
01:19Psychoneuroimmunology: Diabetes and Cancer
360
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
360
01:23Skin Diseases and Disorders
5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
01:25Immunodeficiency Diseases
1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.8K
01:24T Cell Types and Functions
2.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.0K