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Immunoheterogeneity of serum calcitonin in heroin addicts
W Spagnolli1, G DeVenuto, M Mattarei
1Divisione di Medicina 1, Istituti Ospedalieri, Trento, Italy.
Abstract:
Serum calcitonin (CT) concentrations were determined in 96 heroin addicts. CT levels were assayed by radioimmunological method employing two antisera, one vs. the 17-32 fraction (IMN) of the human CT, the other vs. the 11-32 fraction (B7). In heroin addicts the CT mean values were significantly higher (P less than 0.001) than in normal subjects (141 +/- 16.0 and 292 +/- 21.7 pg/ml with IMN-antiserum and with B7-antiserum, respectively, in heroin addicts; 64 +/- 7.8 and 189 +/- 21.7 pg/ml in controls). Serum CT levels assayed with B7-antiserum were notably higher (P less than 0.001) both in controls and in heroin addicts. Our results draw attention to the heterogeneity of high ICT values found in heroin addicts.