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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Exercise and Parkinson's Disease.

Simona Bonavita1

  • 1II Clinic of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy. simona.bonavita@unicampania.it.

Advances in Experimental Medicine and Biology
|April 29, 2020
PubMed
Summary
This summary is machine-generated.

Physical activity may reduce the risk of developing Parkinson's disease (PD) and improve symptoms. This review explores how exercise impacts mobility and cognition in PD patients and animal models.

Keywords:
CognitionExerciseFitnessMagnetic resonance imagingParkinson’s disease

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Area of Science:

  • Neuroscience
  • Gerontology
  • Exercise Science

Background:

  • Parkinson's disease (PD) is a progressive neurodegenerative disorder impacting motor function, with unclear origins involving genetic and environmental factors.
  • Current PD management focuses on symptomatic relief, lacking disease-modifying treatments.
  • Lifestyle factors, particularly physical activity, are increasingly recognized for their potential to influence PD risk and progression.

Purpose of the Study:

  • To review the effects of physical activity on motor and cognitive functions in Parkinson's disease.
  • To examine evidence from both animal models and human studies of PD.
  • To explore the neurobiological links between gait and cognition in the context of PD.

Main Methods:

  • Systematic review of prospective cohort studies and research on animal models of PD.
  • Analysis of neuroimaging studies investigating gait and cognition.
  • Synthesis of findings on physical activity's impact on motor and non-motor symptoms.

Main Results:

  • Growing evidence suggests physical activity can lower PD risk.
  • Exercise may partially ameliorate motor and non-motor symptoms in individuals with PD.
  • Neuroimaging studies reveal structural and functional connections between gait and cognition.

Conclusions:

  • Physical activity is a promising lifestyle factor for potentially reducing Parkinson's disease risk.
  • Exercise interventions may offer benefits for mobility and cognitive function in PD.
  • Understanding the gait-cognition link is crucial for developing comprehensive PD management strategies.