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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Exercise Regulates the Immune System.

Jing Wang1, Shuqin Liu1, Guoping Li2

  • 1Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.

Advances in Experimental Medicine and Biology
|April 29, 2020
PubMed
Summary
This summary is machine-generated.

Regular exercise impacts immune regulation by altering blood cells and cytokines. While beneficial for chronic diseases, it may increase infection susceptibility due to suppressed immunity.

Keywords:
Acute exerciseAdaptive immune systemChronic exerciseInnate immune system

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Area of Science:

  • Immunology
  • Exercise Physiology

Background:

  • Exercise profoundly influences immune system function.
  • Immune regulation and exercise are interconnected, with exercise modulating various immune components.
  • Regular physical activity offers anti-inflammatory benefits, potentially reducing chronic disease risk.

Purpose of the Study:

  • To summarize the mechanisms through which exercise affects immune regulation.
  • To explore both acute and chronic exercise's impact on immunity.

Main Methods:

  • Literature review of studies on exercise and immune response.
  • Analysis of exercise-induced changes in leukocytes, red blood cells, and cytokines.

Main Results:

  • Exercise modulates immune regulation via effects on leukocytes, red blood cells, and cytokines.
  • Regular exercise is linked to reduced chronic disease risk, partly due to anti-inflammatory effects.
  • Intense or prolonged exercise may lead to temporary immune suppression, increasing infection susceptibility.

Conclusions:

  • Exercise exerts significant control over immune regulation through diverse mechanisms.
  • Understanding these mechanisms is crucial for optimizing exercise strategies for health and immunity.