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Updated: Dec 23, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Performance Validity Testing in Multiple Sclerosis.

Rachel Galioto^1,2, Kaltra Dhima², Ophira Berenholz²

¹Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.

Journal of the International Neuropsychological Society : JINS

|April 29, 2020

Summary

This summary is machine-generated.

Nonvalid scores on the Victoria Symptom Validity Test (VSVT) are common in multiple sclerosis (MS) patients. Performance on these tests relates to disability status and mood, not MS-specific factors.

Keywords:

Assessment Cognition Effort Multiple sclerosis Performance validity

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Area of Science:

Neuropsychology
Neurology
Clinical Psychology

Background:

Performance validity tests (PVTs) assess response validity in neuropsychological evaluations.
Understanding factors influencing PVT performance in multiple sclerosis (MS) is crucial for accurate assessment.
Previous research has not fully elucidated the associations between PVTs and MS-specific characteristics.

Purpose of the Study:

To examine Performance Validity Test (PVT) performance in patients with multiple sclerosis (MS).
To investigate the associations between PVT performance and clinical characteristics, cognitive function, mood, and disability status in MS patients.

Main Methods:

Retrospective analysis of 102 MS patients undergoing neuropsychological evaluation.
Comparison with patients with intractable epilepsy (n=102) and mild traumatic brain injury (mTBI; n=50).
Utilized the Victoria Symptom Validity Test (VSVT) with defined validity cutoffs for hard items.

Main Results:

14.4% of MS patients scored below 16/24 and 21.2% below 18/24 on VSVT hard items.
VSVT scores were associated with disability status and depression, but not with cognitive scores, lesion burden, atrophy, or disease duration.
MS patients seeking disability benefits were 6.75 times more likely to score below 18/24.

Conclusions:

Nonvalid VSVT scores are prevalent in MS patients undergoing clinical neuropsychological evaluation.
VSVT performance in MS is linked to disability claims and psychological symptoms, not core MS pathology.
Clinical and research practices should consider these associations when interpreting PVT results in MS.