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Updated: Dec 23, 2025

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Published on: July 4, 2016
Studies of the labile lead pool using a rhodamine-based fluorescent probe
Jianping Zhu1, Jia Hao Yeo, Amy A Bowyer
1University of Sydney, School of Chemistry, Sydney, NSW 2006, Australia. elizabeth.new@sydney.edu.au.
Abstract:
Lead is a heavy metal which has long been known to have toxic effects on the body. However, much remains to be learnt about the labile lead pool and cellular uptake of lead. We report here RPb1 that undergoes a 100-fold increase in fluorescence emission in the presence of Pb2+, and which can be applied to study the labile lead pool within cells. We demonstrate the capacity of RPb1 for investigating labile lead pool in DLD-1 cells and changes in labile lead during differentiation of K562 cells.
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