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Related Experiment Videos

Application of plasminogen polymorphism to forensic hemogenetics.

U Skoda1, A Klein, I Lübcke

  • 1Hygiene-Institut der Universität, Köln, Federal Republic of Germany.

Electrophoresis
|August 1, 1988
PubMed
Summary

Plasminogen (PLG) polymorphism is crucial in forensic genetics, with common alleles PLG*A and PLG*B. This genetic marker meets all criteria for reliable parentage testing.

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Area of Science:

  • Forensic hemogenetics
  • Human genetics
  • Population genetics

Background:

  • Plasminogen (PLG) polymorphism is significant in forensic hemogenetics.
  • PLG exhibits two common codominant alleles (PLG*A, PLG*B), over 18 variants, and a silent allele (PLG*Q0).
  • PLG*A is the most frequent allele globally, with varying frequencies across different ethnic groups.

Purpose of the Study:

  • To evaluate the utility of Plasminogen (PLG) polymorphism in forensic and hemogenetic investigations.
  • To assess the suitability of PLG as a genetic marker for parentage testing.

Main Methods:

  • Phenotype determination using isoelectric focusing followed by functional or immunochemical detection.
  • Analysis of allele frequencies in different populations.

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  • Evaluation of PLG characteristics against prerequisites for genetic markers in parentage expertise.

    • Main Results:

    • PLG*A is the most common allele, with highest frequency in Mongoloids, Amerindians, and Eskimos, and lowest in Caucasoids.
    • The functionally inactive plasminogen M5 variant has been observed exclusively in Japanese individuals.
    • Silent PLG alleles were only found in the heterozygous state; no significant functional differences were noted for other allotypes.
    • PLG polymorphism fulfills Mendelian inheritance, favorable allele distribution, low silent allele frequency, and simple typing technology requirements.

    Conclusions:

    • Plasminogen (PLG) polymorphism is a valuable tool in hemogenetic investigations and forensic science.
    • The PLG system meets the essential criteria for its application in parentage testing, offering a 17.2% exclusion chance in European Caucasoids.